"Bystander Effects of Antibody Drug Conjugates on the Hematopoietic Compartment"

Evaluation of ADC Toxicity

Clarke E.,¹Huang Y.,¹ Dos Santos G.,¹ Society of Toxicology 57^th Annual Meeting & ToxExpo 2018, Poster Abstract No. 2325 . ¹ ReachBio Research Labs, Seattle, WA.

“An Ex Vivo Flow Cytometry Platform to Evaluate the Effects of Compounds on Lymphotoxicity in Multiple Species”

Lymphotoxicity in Multiple Species

Dos Santos G.,¹ Clarke E.,¹ Society of Toxicology 56^th Annual Meeting & ToxExpo 2017, Poster Abstract No. 261 . ¹ ReachBio Research Labs, Seattle, WA.

“An Ex Vivo Platform to Evaluate Compound Effects on Erythroid and Megakaryocyte Development”

Erythroid and Megakaryocyte Development

Dos Santos G.,¹ Clarke E.,¹ Society of Toxicology 55^th Annual Meeting & ToxExpo 2016, Poster Abstract No. 139 . ¹ ReachBio Research Labs, Seattle, WA.

Erythroid and Meg Development poster thumb

“An Ex Vivo Megakaryocyte Platform to Evaluate the Effects of Compounds on Different Stages of Platelet Development”

Platelet Development

Dos Santos G.,¹ Rosser J.,¹ Clarke E.,¹ Society of Toxicology 54^thAnnual Meeting & ToxExpo 2015, Poster Abstract No. 402 . ¹ ReachBio Research Labs, Seattle, WA.

“Comparison of 3 Methods for the Evaluation of Cytokine Storm Risk in Early and Clinical Stage Biopharmaceutical Development”

Cytokine Storm Studies

Dos Santos G.,¹ Clarke E.,¹ Society of Toxicology 53^rd Annual Meeting & ToxExpo 2014, Poster Abstract No. 270 . ¹ReachBio, Seattle, WA.

“An Ex Vivo Platform to Evaluate the Differential Effects of Potential Therapies on Leukemia Progenitors (CFU-L) vs Normal Bone Marrow Progenitors (CFU-GM)”

Cancer Stem Cells

Clarke E.,¹ Kyriss B.,¹ Mergaert A.,¹ Society of Toxicology 53^rd Annual Meeting & ToxExpo 2014, Poster Abstract No. 1920 . ¹ReachBio, Seattle, WA.

“Colony Forming Cell (CFC) Assays Predict for Increased Clinical Neutropenia with Combination Therapies”

Combination Therapy Studies

Dos Santos G.,¹ Mergaert A.,¹ Clarke E.,¹ Society of Toxicology 52^nd Annual Meeting & ToxExpo 2013, Poster Abstract No. 1198 . ¹ReachBio, Seattle, WA.

“Effects of Tyrosine Kinase 2 Inhibitors on Megakaryocyte Development”

TKI Toxicity in Bone Marrow

Uppal H.,¹ Danilenko D.,¹ Harstad E.,¹ Tarrant J.,¹ Clarke E.,² Dhawan P.,¹ Kauss, A.,¹ McCray B.,¹ Misner D.,¹ Singh J.,¹ Society of Toxicology 52^nd Annual Meeting & ToxExpo 2013, Poster Abstract No. 1819 . ¹Safety Assessment, Genentech Inc., San Ramon, CA; ²ReachBio, Seattle, WA.

“ISMTR-283 Protects Human Bone Marrow Progenitors from the Lethal Effects of Ionizing Radiation”

Radioprotection Studies

Clarke E.,¹ Traynor-Kaplan A.,² Society of Toxicology 51^st Annual Meeting & ToxExpo 2012, Poster Abstract No. 218 . ¹ReachBio, Seattle, WA; ²ISM Therapeutics, Seattle, WA.

“Effects of Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors on Platelet Development”

Platelet Development

Singh J.,¹ Zabka T.,¹ Uppal H.,¹ Diaz D.,¹ Tarrant J.,¹ Clarke E.,² Lin T.,¹ La N.,¹ McCray B.,¹ Nguyen T.,¹ Dhawan P.,¹ Doudement E.,¹ Kauss A.,¹ Dambach D.,¹ Misner D.,¹ Society of Toxicology 52^nd Annual Meeting & ToxExpo 2013, Poster Abstract No. 2179 . ¹Safety Assessment, Genentech Inc., South San Francisco, CA; ²ReachBio, Seattle, WA.

“Differential Toxicities of Kinase Inhibitors (KI) on Bone Marrow Progenitors from Different Species”

Differential Effects of Kinase Inhibitors in Multiple Species

Clarke E.,¹ Dos Santos G.,¹ Society of Toxicology 50^th Annual Meeting & ToxExpo 2011, Poster Abstract No. 1172 . ¹ReachBio, Seattle, WA, USA.

“Reliable and Predictive In Vitro Assays for Myelotoxicity and Cardiotoxicity of Kinase Inhibitors”

Myelotoxicity and Cardiotoxicity Assays for Kinase Inhibitors

Clarke E.,¹ Schwengberg S.,² Kettenhofen R.,² Dos Santos G.,¹ Bohlen H.,² Society of Toxicology 48^th Annual Meeting & ToxExpo 2009, Poster Abstract No. 1851 . ¹ReachBio, Seattle, WA, USA; ²Axiogenesis AG, Cologne, Germany.