References
SERVICES-
ADC Linker Stability Assay
Canals Hernaez, Diana, et al. Front. Oncol., 04 May 2022 The Biomedical Research Centre and School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada https://www.frontiersin.org/articles/10.3389/fonc.2022.856424/full -
Multiple Myeloma CFC Assay
Byrgazov, Konstantin1; Besse, Andrej2; Kraus, Marianne2; Slipicevic, Ana1; Lehmann, Fredrik1; Driessen, Christoph2; Besse, Lenka2 Hemasphere. 2021 Jul; 5(7): e602. Oncopeptides AB, Stockholm, Sweden
https://journals.lww.com/hemasphere/Fulltext/2021/07000/Novel_Peptide_drug_Conjugate_Melflufen_Efficiently.7.aspx -
Compound Effects on Human Myeloid and Erythroid Progenitors Using CFC Assays
Nathan O. Fuller, Antonella Pirone, Berkley A. Lynch, Michael C. Hewitt, Maria S. Quinton, Timothy D. McKee, and Magnus Ivarsson; ACS Chem. Neurosci. 2019, 10, 3, 1729–1743; Rodin Therapeutics, Cambridge, MA USA https://pubs.acs.org/doi/full/10.1021/acschemneuro.8b00620 -
Primary bone marrow sample colony formation assay
Min C., Moore N., Shearstone J., Quayle S., Huang P., van Duzer J., Jarpe M., Jones S., and Yang M. PLOS One. 2017; 12(1): e0169128. 2017 Jan 1. Acetylon Pharmaceuticals Inc., Boston, MA, United States of America
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218480/ -
Burst forming unit erythroid (BFU-E) assays
Shearstone J., Golonzhka O., Chonkar A., Tamang D., van Duzer J., Jones S., and Jarpe M. PLoS One. 2016; 11(4): e0153767. 2016 April 4. Acetylon Pharmaceuticals Inc., Boston, MA, United States of America
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830539/ -
Myeloid colony forming assays to assess Jak2 cellular activity
A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation
Ferguson G.,1,* Delgado M.,2 Plantevin-Krenitsky V.,2 Jensen-Pergakes K.,5 Bates R.,1 Torres S.,1 Celeridad M.,1 Brown H.,3 Burnett K.,3 Nadolny L.,2 Tehrani L.,2 Packard G.,2 Pagarigan B.,4 Haelewyn J.,4 Nguyen T.,4 Xu L.,1 Tang Y.,3 Hickman M.,4 Baculi F.,4 Pierce S.,4 Miyazawa K.,6 Jackson P.,4 Chamberlain P.,4 LeBrun L.,4 Xie W.,1 Bennett B.,1 and Blease K. 3 PLoS One. 2016; 11(1): e0145705. 2016 Jan 12. Department of Inflammation Research, Celgene Corporation, San Diego, CA, United States of America
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710522/ -
Human and mouse bone marrow toxicity studies (Microtubule Inhibitor targeting Tumors)
A Novel Microtubule Inhibitor 4SC-207 with Anti-Proliferative Activity in Taxane-Resistant Cells
Bausch E.,1 Kohlhof H.,2 Hamm S.,3 Krauss R.,2 Baumgartner R.,2 Sironi L.,1 PLOS one, 8(11): 1-14, November 2013. 1 Department of Biology and Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany, 2 4SC AG, Planegg – Martinsried, Germany, 3 4SC Discovery GmbH, Planegg, Martinsried, Germany.
http://www.ncbi.nlm.nih.gov/pubmed/?term=A+Novel+Microtubule+Inhibitor+4SC-207+with+Anti-Proliferative+Activity+in+Taxane-Resistant+Cells -
Human bone marrow toxicity studies (Anti-Viral Combination drug studies)
Lam A.,1 Espiritu C.,1 Murakami E.,1 Zennou V.,1 Bansal S.,1 Micolochick Steuer H.M.,1 Niu, C.,1 Keilman M.,1 Bao H.,1 Bourne N.,2 Veselenak R.L.,2 Reddy P.G.,1 Chang W.,1 Du J.,1 Nagarathnam D.,1 Sofia M.J.,1 Otto M.J.,1 Furman P.A.,1 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 55(6): 2566–2575, June 2011. 1Pharmasset, Inc., Princeton, NJ, 2University of Texas Medical Branch, Galveston, TX.
https://journals.asm.org/doi/10.1128/AAC.00032-11Furman P.A.,1 Murakami E.,1 Niu C.,1 Lam A.M.,1 Espiritu C.,1 Bansal S.,1 Bao H.,1 Tolstykh T.,1 Micolochick Steuer H.,1 Keilman M.,1 Zennou V.,1 Bourne N., 2 Veselenak R.L.,2 Chang W.,1 Ross B.S.,1 Du J.,1 Otto M.J.,1 Sofia M.J.,1 Antiviral Research, 91: 120–132, 2011. 1Pharmasset, Inc., East Princeton, NJ, USA, 2University of Texas Medical Branch, Galveston, TX, USA.
http://www.ncbi.nlm.nih.gov/pubmed/?term=Activity+and+the+metabolic+activation+pathway+of+the+potent+and+selective+hepatitis+C+virus+pronucleotide+inhibitor+PSI-353661 -
Human bone marrow toxicity studies (Anti-Viral drug study)
Lam A.M.,1 Murakami E.,1 Espiritu C.,1 Micolochick Steuer H.M,1 Niu C.,1 Keilman M.,1 Bao H.,1 Zennou V.,1 Bourne N.,2 Julander J.G.,3 Morrey J.D.,3 Smee D.F.,3 Frick D.N.,4 Heck J.A.,4 Wang P.,1 Nagarathnam D.,1 Ross B.S.,1 Sofia M.J.,1 Otto M.J.,?1 Furman P.A.,1 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(8): 3187–3196, Aug 2010. 1Pharmasset, Inc., Princeton, NJ; 2University of Texas Medical Branch, Galveston,TX; 3Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT; 4Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY.
http://www.ncbi.nlm.nih.gov/pubmed/?term=PSI-7851%2C+a+Pronucleotide+of+%CE%B2-%E1%B4%85-2%E2%80%99-Deoxy-2%E2%80%99-Fluoro-2%E2%80%99-C-Methyluridine+Monophosphate%2C+Is+a+Potent+and+Pan+Genotype+Inhibitor+of+Hepatitis+C+Virus+ReplicationSofia M.J.,1 Bao D.,1 Chang W.,1 Du J.,1 Nagarathnam D.,1 Rachakonda S.,1 Reddy P.G.,1 Ross B.S.,1 Wang P.,1 Zhang H.,1 Bansal S.,1 Espiritu C.,1 Keilman M.,1 Lam A.M.,1 Micolochick-Steuer H.M.,1 Niu C.,1 Otto M.J.,1 Furman P.A.,1 J. Med. Chem., 53: 7202–721, 2010. 1Pharmasset, Inc., Princeton, NJ.
https://www.ncbi.nlm.nih.gov/pubmed/20845908 -
Human bone marrow toxicity studies (Myelosuppressive Oncology Drugs)
Maier M.,1 Toxicology Mechanisms and Methods, 21(2): 76–85, 2011. 1Cambrex Corporation, Charles City, IA, USA.
http://www.ncbi.nlm.nih.gov/pubmed/?term=Setting+occupational+exposure+limits+for+unstudied+pharmaceutical+intermediates+using+an+in+vitro+parallelogram+approach -
Human bone marrow toxicity studies (Tyrosine Kinase Inhibitors)
Joshi R.,1 Kanekal S.,1 Redkar S.,1 Berk G.,1 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics 2008, Poster Abstract No. 480 . 1Supergen Inc., Dublin, CA, USA.
https://www.researchgate.net/publication/246490000_480_POSTER_MP470_a_novel_multi-targeted_tyrosine_kinase_inhibitor_targeting_rad51_is_not_toxic_to_human_primary_marrow_stem_cells_at_clinically_relevant_concentrations?ev=auth_pub -
Human and mouse bone marrow toxicity studies (Chemotherapeutic Agents)