Radioprotective and Radiorecovery Compounds
Ionizing radiation (e.g. due to intensive radiotherapy, radiological/nuclear incident or act of terrorism) can produce deleterious dose-dependent effects in living tissues, leading to significant morbidity and a potentially fatal illness affecting various organs.
Radiosensitivity is the relative susceptibility of cells, tissues, organs, organisms, or other substances to the injurious effects of radiation. In general, it has been found that cell radiosensitivity is directly proportional to the rate of cell division and inversely proportional to the degree of cell differentiation. In short, this means that actively dividing cells or those not fully mature are most at risk from radiation. Therefore, there is great interest in the development of effective radioprotectors and radiorecovery drugs for the hematopoietic system, which is continuously producing cells.
- Utilize primary hematopoietic progenitor and mesenchymal (stromal) cell assays to evaluate compounds for potential radioprotective and radiation-sparing effects