Publications

References

HbF Induction Assay

"The BACH1 Inhibitor ASP8731 Inhibits Inflammation and Vaso-occlusion and Induces Fetal Hemoglobin in Sickle Cell Disease"

John D. Belcher¹, Selvaraj Nataraja², Fuad Abdulla¹, Ping Zhang¹, Chunsheng Chen¹, Julia Nguyen¹, Conglin Ryan¹, Maneet Singh², Shipla Demes³, Lyndsay Olson², Domi Stickens², Jeff Stanwix², Emer Clarke⁴, Yongzhao Huang⁴, Margaret Biddle², and Gregory M. Vercellotti¹| ¹ Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, United States | ²Mitobridge Inc., Cambridge, MA, United States | ³Astellas Pharma Global Development Inc., Northbrook, IL, United States | ⁴ ReachBio, Seattle, WA, United States

ADC Linker Stability Assay

"Targeting a Tumor-Specific Epitope on Podocalyxin Increases Survival in Human Tumor Preclinical Models"

D. Hernaez¹, M.R. Hughes¹, Y.Li¹, I.M. Rocca², P. Dean³, J. Brassard¹, E.M. Bell³, I. Samudio⁴, A. Mes-Masson⁵, Y. Narimatsu⁶, H. Clausen⁶, O. Blixt², C.D. Roskelley^3* and K.M. McNagny^1*Front. Oncol., 04 May 2022. ¹The Biomedical Research Centre and School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, ²Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark, ³Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada, ⁴Centre for Drug Research and Development, Vancouver, BC, Canada, ⁵Department of Medicine,Institut du Cancer de Montreal, Montreal, QC, Canada, ⁶Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine (ICMM), University of Copenhagen, Copenhagen, Denmark

HbF Induction Assay

"A Novel BACH1 Inhibitor That Induces Fetal Hemoglobin in Treatment of Sickle Cell Disease"

Selva Nataraja, PhD, Maneet Singh, PhD, Shilpa Demes, PhD, Lyndsay Olson, Jeff Stanwix, Margaret Biddle, PhD, Emer Clarke, PhD, Yongzhao Huang, Julia Nguyen, Chunsheng Chen, PhD, Ping Zhang, PhD, Fuad Abdulla, Gregory M. Vercellotti, MD and John D Belcher, PhD, ASH 2022 Mitobridge, Cambridge, MA

CFC Assay

"CoREST Complex-Selective Histone Deacetylase Inhibitors Show Prosynaptic Effects and an Improved Safety Profile To Enable Treatment of Synaptopathies"

Fuller N., Pirone A., Lynch B., Hewitt M., Quinton M., McKee T., and Ivarsson M., ACS Chem. Neurosci. 10-21, 2018. Rodin Therapeutics, Cambridge, Massachusetts.

Predicting Thrombocytopenia

“Preclinical Models of Nicotinamide Phosphoribosyltransferase Inhibitor-Mediated Hematotoxicity and Mitigation by Co-treatment with Nicotinic Acid“

Tarrant J.M.,^1*Dhawan P.,¹Singh J.,^1,2Zabka T.S.,¹Clarke E.,³Dos Santos G.,³Dragovich P.S.,⁴Sampath D.,⁵Lin T.,¹McCray B.,¹La N.,¹ Nguyen T.,¹ Kauss A.,¹ Dambach D.,¹ Misner D.L.,¹ Diaz D.,¹ Uppal H.,^1,6. Toxicology Mechanisms and Methods: 1-11, April 20 2015 (early online). ¹Department of Safety Assessment, Genentech Inc, South San Francisco, CA, USA, ²Retrophin Inc, Cambridge, MA, USA, ³ReachBio, Seattle, WA, USA, ⁴Department of Discovery Chemistry and ⁵Department of Translational Oncology, Genentech Inc, South San Francisco, CA, USA, and ⁶Medivation, San Francisco, CA, USA.

CML (Clinical Trial Samples)

“Dasatinib Plus Smoothened (SMO) Inhibitor BMS-833923 in Chronic Myeloid Leukemia (CML) with Resistance or Suboptimal Response to a Prior Tyrosine Kinase Inhibitor (TKI): Phase I Study CA180323”

Shah N.P.,¹ Cortes J.E.,² Martinelli G.,³ Smith B.D.,⁴ Clarke E.,⁵ Copland M.,⁶ Strauss L.,⁷ Talpaz M.,⁸. Blood: 4539-4539, 124 (21). ¹University of California, San Francisco, CA, USA; ²The University of Texas MD Anderson Cancer Center, Houston, TX, USA; ³University of Bologna, Bologna, Italy; ⁴Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA; ⁵ReachBio LLC, Seattle, WA, USA; ⁶University of Glasgow, Glasgow, United Kingdom; ⁷Bristol-Myers Squibb, Wallingford, CT, USA; ⁸The University of Michigan Hospital and Health Systems-Comprehensive Cancer Center, Ann Arbor, MI, USA.

BFU-E Assay

"Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2"

Shearstone J., Golonzhka O., Chonkar A., Tamang D., van Duzer J., Jones S., Jarpe M., PLoS One. April 13, 2016. Acetylon Pharmaceuticals, Boston, Massachusetts.

Stem Cell Sciences

“Introduction to Stem Cell Science”

Ennis C., Clarke E.,¹ Lannon, C., Atkinson E.,² Quantum Scientific Publishing, 1-284, 2012. ¹ReachBio LLC, ² BroadReach Biosystems.

Mesenchymal Stem Cells

“Mesenchymal Stem Cell Mechanics from the Attached to the Suspended State”

Maloney J.M.,¹ Nikova D.,¹ Lautenschläger F.,² Clarke E.,³ Langer R.,^4,5 Guck J.,² Van Vliet K.J.,^1,5 Biophysical Journal, 99: 2479-2487, October 2010. ¹Department of Materials Science and Engineering, ⁴Department of Chemical Engineering, and ⁵Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts; ²Department of Physics, Cavendish Laboratory, University of Cambridge, Cambridge, United Kingdom; and ³ReachBio, Seattle, Washington.