2023 Icon

HbF Induction Assay

"The BACH1 Inhibitor ASP8731 Inhibits Inflammation and Vaso-occlusion and Induces Fetal Hemoglobin in Sickle Cell Disease"

John D. Belcher1, Selvaraj Nataraja2, Fuad Abdulla1, Ping Zhang1, Chunsheng Chen1, Julia Nguyen1, Conglin Ryan1, Maneet Singh2, Shipla Demes3, Lyndsay Olson2, Domi Stickens2, Jeff Stanwix2, Emer Clarke4, Yongzhao Huang4, Margaret Biddle2, and Gregory M. Vercellotti1 Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, United States | 2 Mitobridge Inc., Cambridge, MA, United States | 3 Astellas Pharma Global Development Inc., Northbrook, IL, United States | 4 ReachBio, Seattle, WA, United States

2022 Icon-1

ADC Linker Stability Assay

"Targeting a Tumor-Specific Epitope on Podocalyxin Increases Survival in Human Tumor Preclinical Models"

D. Hernaez1, M.R. Hughes1, Y.Li1, I.M. Rocca2, P. Dean3, J. Brassard1, E.M. Bell3, I. Samudio4, A. Mes-Masson5, Y. Narimatsu6, H. Clausen6, O. Blixt2, C.D. Roskelley3* and K.M. McNagny1*  Front. Oncol., 04 May 2022. 1The Biomedical Research Centre and School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, 2Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark, 3Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada, 4Centre for Drug Research and Development, Vancouver, BC, Canada, 5Department of Medicine,Institut du Cancer de Montreal, Montreal, QC, Canada, 6Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine (ICMM), University of Copenhagen, Copenhagen, Denmark

2022 Icon

HbF Induction Assay

"A Novel BACH1 Inhibitor That Induces Fetal Hemoglobin in Treatment of Sickle Cell Disease" 

Selva Nataraja, PhD, Maneet Singh, PhD, Shilpa Demes, PhD, Lyndsay Olson, Jeff Stanwix, Margaret Biddle, PhD, Emer Clarke, PhD, Yongzhao Huang, Julia Nguyen, Chunsheng Chen, PhD, Ping Zhang, PhD, Fuad Abdulla, Gregory M. Vercellotti, MD and John D Belcher, PhD, ASH 2022 Mitobridge, Cambridge, MA

2018 icon-1

CFC Assay

"CoREST Complex-Selective Histone Deacetylase Inhibitors Show Prosynaptic Effects and an Improved Safety Profile To Enable Treatment of Synaptopathies"

Fuller N., Pirone A., Lynch B., Hewitt M., Quinton M., McKee T., and Ivarsson M.,  ACS Chem. Neurosci. 10-21, 2018. Rodin Therapeutics, Cambridge, Massachusetts.

2015 Icon

Predicting Thrombocytopenia

Preclinical Models of Nicotinamide Phosphoribosyltransferase Inhibitor-Mediated Hematotoxicity and Mitigation by Co-treatment with Nicotinic Acid

Tarrant J.M.,1* Dhawan P.,Singh J.,1,2  Zabka T.S.,Clarke E.,Dos Santos G.,Dragovich P.S.,Sampath D.,Lin T.,McCray B.,La N.,1 Nguyen T.,1 Kauss A.,1 Dambach D.,1 Misner D.L.,1 Diaz D.,1 Uppal H.,1,6. Toxicology Mechanisms and Methods: 1-11, April 20 2015 (early online). 1Department of Safety Assessment, Genentech Inc, South San Francisco, CA, USA, 2Retrophin Inc, Cambridge, MA, USA, 3ReachBio, Seattle, WA, USA, 4Department of Discovery Chemistry and 5Department of Translational Oncology, Genentech Inc, South San Francisco, CA, USA, and 6Medivation, San Francisco, CA, USA.

2014 Icon

CML (Clinical Trial Samples)

“Dasatinib Plus Smoothened (SMO) Inhibitor BMS-833923 in Chronic Myeloid Leukemia (CML) with Resistance or Suboptimal Response to a Prior Tyrosine Kinase Inhibitor (TKI): Phase I Study CA180323”

Shah N.P.,1 Cortes J.E.,2 Martinelli G.,3 Smith B.D.,4 Clarke E.,5 Copland M.,6 Strauss L.,7 Talpaz M.,8. Blood: 4539-4539, 124 (21). 1University of California, San Francisco, CA, USA; 2The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 3University of Bologna, Bologna, Italy; 4Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA; 5ReachBio LLC, Seattle, WA, USA; 6University of Glasgow, Glasgow, United Kingdom; 7Bristol-Myers Squibb, Wallingford, CT, USA; 8The University of Michigan Hospital and Health Systems-Comprehensive Cancer Center, Ann Arbor, MI, USA.

2016 Icon

BFU-E Assay

"Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2"

Shearstone J., Golonzhka O., Chonkar A., Tamang D., van Duzer J., Jones S., Jarpe M., PLoS One. April 13, 2016. Acetylon Pharmaceuticals, Boston, Massachusetts.

2012 Icon

Stem Cell Sciences

Introduction to Stem Cell Science 

Ennis C., Clarke E.,1 Lannon, C., Atkinson E.,2 Quantum Scientific Publishing, 1-284, 2012.  1ReachBio LLC, 2 BroadReach Biosystems.

2010 Icon

Mesenchymal Stem Cells

Mesenchymal Stem Cell Mechanics from the Attached to the Suspended State

Maloney J.M.,1 Nikova D.,1 Lautenschläger F.,2 Clarke E.,3 Langer R.,4,5 Guck J.,2 Van Vliet K.J.,1,5 Biophysical Journal, 99: 2479-2487, October 2010. 1Department of Materials Science and Engineering, 4Department of Chemical Engineering, and 5Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts; 2Department of Physics, Cavendish Laboratory, University of Cambridge, Cambridge, United Kingdom; and 3ReachBio, Seattle, Washington.