We work with a variety of compound classes ranging from small molecules to large complex biologics. Whether the project is screening a batch of compounds for toxicity testing, studying mechanism of action of a particular compound or evaluating compound efficacy, we work with our clients to employ the most appropriate assays to tackle these questions.

Compound Classes

Typical Compound Types Tested in our Primary Cell-Based Assays
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Biologics

Since many biologics are forms of naturally occurring human molecules, they’re able to target their intended ligands more specifically than many small molecules, which often have undesirable promiscuity and off-target effects.

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Antivirals

ReachBio works with clients during preclinical development of antiviral agents to help them predict and rank the potential of their drug candidates to induce myelosuppression (anemia, neutropenia, thrombocytopenia).

 

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Small Molecules

We use a variety of assays for ascertaining efficacy and toxicity questions with our clients’ small molecule compounds. 

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Kinase Inhibitors

TKIs have shown remarkably high response rates for a number of diseases, spurring intense interest in the development of novel TKIs targeting a variety of disease-associated kinases.

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Chemotherapeutics

Since chemotherapeutic agents have the greatest effect on rapidly dividing cells without discriminating normal vs. cancer cells, common side affects are gastrointestinal toxicity and myelosuppression.

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Combination Therapies

For a growing number of diseases (e.g. AML, CML, MM, and NHL), combination therapies are being employed, due in part to their superior efficacy compared to monotherapies.

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Antibody-Based Biologics

We have helped many clients evaluate their antibody-based therapeutic candidates for both functionality and potential toxicity.

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Industrial & Environmental Toxins

 Studies on environmental compounds show their ability to exhibit toxicity on the hematopoietic system. Many compounds can be evaluated for hematotoxicity using in vitro CFC assays.

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Radioprotective and Radiorecovery Compounds

Our services utilize primary hematopoietic progenitor and mesenchymal (stromal) cell assays to evaluate compounds for potential radioprotective and radiation-sparing effects.
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