We work with a variety of compound classes ranging from small molecules to large complex biologics. Whether the project is screening a batch of compounds for toxicity testing, studying mechanism of action of a particular compound or evaluating compound efficacy, we work with our clients to employ the most appropriate assays to tackle these questions.

Compound Classes

Typical Compound Types Tested in our Primary Cell-Based Assays
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Antibody-Based Biologics

We evaluate antibody-based therapeutic candidates for both functionality and potential toxicity.

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Antibody Drug Conjugates

Some ADCs have had significant off-target toxicities causing neutropenia and thrombocytopenia. 

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Antivirals

Predict and rank the potential of antiviral candidates to induce myelosuppression (anemia, neutropenia, thrombocytopenia) during preclinical development.

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Biologics

Many biologics are forms of naturally occurring human molecules that can have off-target effects.

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CAR-T Cells

We ascertain efficacy and toxicity questions for CAR-T cell therapies that are engineered to destroy cancer.

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Chemotherapeutics

Common side affects of these agents are gastrointestinal toxicity and myelosuppression.

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Combination Therapies

The benefits of combination therapy over monontherapy are numerous, but this type of treatment often comes with increased toxicity.

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Industrial & Environmental Toxins

 Many environmental compounds can be evaluated for hematotoxicity using in vitro CFC assays.

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Radioprotective

Primary hematopoietic progenitor and mesenchymal cell assays evaluate compounds for potential radioprotective and radiation-sparing effects.

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Small Molecules

We have assays for ascertaining efficacy and toxicity questions with small molecule compounds.

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