IN VITRO SERVICES
Our expertise covers many aspects of primary cell biology with a special emphasis on hematopoietic (blood and bone marrow) primary cell systems. We assist clients with early stage research projects through multiple areas of pre-clinical and clinical drug development.
We go out of our way to ensure your project’s success, including full and immediate access to project scientists, responsive and thorough communication and a quick turn-around time of information and data.
The sections below will provide you with more information about our range of in vitro service offerings. Please keep in mind that in addition to our standard contract assay services, we also offer customized contract research services in various areas of primary cell biology.
Please CONTACT US to discuss your project needs.
Expect
- Full confidentiality
- Frequent consultation with study director
- Rapid turnaround of contract paperwork (e.g. CDA, MSA)
- Assay selection and design (e.g. cell type, species)
- Protocol design
- Study execution
- Data interpretation
- Full written report
- Follow-up consultation
IN VITRO
Services
cellPrism®
Our predictive assays can be applied to a variety of program challenges including neutropenia, thrombocytopenia, and immuno-oncology. By using primary cells in our assays we’re able to provide clients with the best clinically relevant data, including high content readouts for numerous blood diseases and disorders.
ADCC Assay
ADCC assays allow clients to evaluate and rank their mAb candidates ability to kill tumor/cancer cells through NK mediated cell lysis. This assay is suitable for antibody drug research and development and is compatible with bi-specific antibodies and other immune cell recruiters.
Cancer Stem Cell + Leukemic CFC Assays
We can culture various hematopoietic cancer stem and/or progenitor cells in leukemic CFU-L colony-forming cell assays and evaluate the effects of test compounds on these cells.
CFC Assays
Colony assays are predictive and validated. The CFC assay has been found to be particularly valuable at predicting drug-induced neutropenia and myelosuppression and determining maximum tolerated dose (MTD).
Myelosuppression + Hematotoxicity Assays
Predictive in vitro assays for assessing the hemotoxicity or myelotoxic liability of compounds.
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Biotherapeutics Development Support
Our experience supporting biotherapeutic development includes assays to evaluate primary cell functionality and toxicity of monoclonal antibodies, bi-specific antibodies, antibody-drug conjugates, nanobodies and other biologics.
Co-Culture Systems
A number of in vitro systems have been developed in which two or more different cell types are cultured together to more closely replicate the environment of the in vivo niche of the test cells than culturing the cells in isolation can provide. Our scientists have experience in using a variety of primary cell and cell-line co-culture systems to test the effects of test compounds on certain cell types.
Compound Classes
We work with a variety of compound classes ranging from small molecules to large complex biologics. Whether the project is screening a batch of compounds for toxicity testing, studying mechanism of action of a particular compound or evaluating compound efficacy.
Custom Cell Biology Research
When your projects require expert cell biology services, our lab can prepare replicate vials of in vitro cell populations, evaluate compounds in unique in vitro models, and a variety of custom services.
Immune Profiling & Flow Cytometry
Biotherapeutics development often requires a deep understanding of their effects on the entire immune cell system. Our expertise includes flow cytometry profiling of cell surface markers and intracellular staining to look at master regulatory proteins.
Pre-Clinical & Clinical Samples
We can accept samples from single institutions or multiple centers for analysis. We readily accept peripheral blood, bone marrow and mobilized peripheral blood from multiple species to support preclinical studies.
Primary Cell Bank Generation
We offer cell banking services for both human and mouse primary cells and cell lines. We have experience in banking challenging types of cells, including primary lymphocyte subsets.
