Industrial and Environmental Toxins

Sustained exposure to a variety of chemicals in food, air, water and household products raises concerns of potential health hazards.  Studies on a variety of environmental compounds show their ability to exhibit various degrees of toxicity on the hematopoietic system. Many of these compounds can be evaluated for hematotoxicity using in vitro CFC (colony-forming cell) assays.

Examples of environmental toxic compounds include:
  • Industrial pollutants such as lead and cadmium heavy metals [1,2]
  • Benzene metabolites [1,2,5]
  • Halogenated aromatic compounds, such as polychlorinated biphenyls (PCBs)[1] and dioxins (e.g. TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin)[3]
  • Pesticide toxicity (e.g. lindane [1,4], parathion and malathion metabolites)[6] has been evaluated with the CFC assay
Our assay services include:
  • Determination of myelosuppression (lineage-specific toxicity of the various hematopoietic progenitors) caused by toxins using CFC assays.
References:
1.  R.L. Van Den Heuvel et. al., Cell biology and Toxicology. 2001; 17: 107-116
2.  R.L. Van Den Heuvel et. al., Cell biology and Toxicology. 1999; 15: 101-110
3.  B.I. Yoon et al., Arch. Environ. Contam. Toxicol. 2001; 41: 232-236
4.  D. Parent-Massin et al., Hum Exp Toxicol. 1994; 13: 103-106
5.  L. Zhang et. al., Chem Biol Interact. 2010, March 19; 184(1-2): 86-93
6.  V.S. Gallicchio et. at., Exp. Hematol. 1987, Dec; 15(11): 1099-102