Predict thrombocytopenia at the preclinical drug development stage.
These in vitro assays replicate in vivo cell biology conditions. We incubate primary bone marrow cells with your test compounds in a collagen-based matrix containing specific growth factors. We then fix and stain the cultures for CD41, count the colonies, and provide you with a detailed report on your drug’s off-target toxicity impact.
The preclinical screening method that helps clients eliminate bad players earlier in the drug development process. Whitepaper
A quick reference resource for scientists who need to isolate, manipulate, or develop assays involving human mononuclear cells. Video
This in vitro assay has been validated by ECVAM (European Centre for the Validation of Alternative Methods) and correlates well with clinical neutropenia for many drug classes. Protocol