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Home > Pure Cardiomyocytes

 

Cardiomyocyte Products

 

ReachBio is the Exclusive North American Distributor for Axiogenesis AG, including the Cor.At® product line of pure cardiomyocytes and related products.  For a list of products, please click here.

 

Cor.At®: Ready-To-Use Pure Cardiomyocytes

 

Cor.At® atrial cardiomyocytes are produced and genetically selected from mouse embryonic stem (ES) cells using cutting edge technology. They are 99.9% pure, ready to use and functionally normal. They exhibit autonomous contractility and embryonic electrophysiological and gene expression phenotypes. These transgenic cardiomyocytes express green fluorescent protein (GFP) reporter gene driven by a cardiac-specific promoter (α-MHC). The cells generate cardiac-specific connexin 43 and show electrical coupling demonstrated by their synchronous contractions.

 

Major applications include:

 

  • Predictive cardiotoxicity screening

    -   morphological changes

    -   viability

    -   biomarker release (e.g. troponin)

    -   etc.

     

Flyer

Technical Bulletin

 

 

  • In-vitro model of hypertrophy

    -   reproduce features of hypertrophic cardiomyocytes

        when stimulated with specific agonists

            --  increased cell size and sarcomeric organization

            --  upregulation of hypertrophy-specific genes

     

Flyer

Technical Bulletin

  • Electrophysiology studies

    -   Represent an authentic cellular environment that

        includes all cardiac ion channels (Na+, Ca2+, K+)

    -   hERG blocker effects

    -   chronotrophic effects

    -   arrhythmic effects

    -   Correct humoral regulation

    -   Adrenergic and muscarinic effects

     

Flyer

Technical Bulletin

  • Basic R&D

    -   Transplantation experiments

    -   Studies of cardiac gene expression in response to

        stimuli

     

Technical Bulletin

  • Automated Instruments

 

 

-   PatchXpress® 7000A

Technical Bulletin

 

-   QPatch

   
 

-   xCELLigence™

Application Note

 

-   Port-a-Patch®

Application Note

 

-   Patchliner®

Application Note

 

Flyer

 

PatchXpress® is a registered trademark of MDS Analytical Technologies

xCELLigence  is a trademark of Roche

Cor.At® is a registered trademark of Axiogenesis AG

Port-a-Patch® and Patchliner® are registered trademarks of Nanion Technologies GmbH

 

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Axiogenesis Cor.At® Products

 

Product

Description

Unit/Format

ReachBio Cat. #

Cor.At® Cells (vials)

Cor.At® GFP Cardiomyocytes

•  99.9% pure

•  1 million or 5 million viable cells/vial

•  100 mL Cor.At® Culture Medium for 1 million cells

•  500 mL Cor.At® Culture Medium for 5 million cells

Cryo Vial

06101

(1 million)

 

06103

(5 million)

Cor.At® CL Cells (vials)

Cor.At® non-GFP Cardiomyocytes

•  99.9% pure

•  1 million cells/vial

•  100 mL Cor.At® Culture Medium

Cryo Vial

06301

Cor.At® Culture Medium

Culture Medium for Cor.At® cardiomyocytes

•  Optimized formulation

•  Contains pre-qualified supplements

100 mL

250 mL

06089

(100 mL)

06099

(250 mL)

Cor.At® RNA (Day 2)

Purified RNA from day 2 cultures of Cor.At® cardiomyocytes

1 ug

06121

Cor.At® RNA

(Day 14)  

Purified RNA from day 14 cultures of Cor.At® cardiomyocytes

1 ug

06122

Cor.At® RNA

(Day 2 & 14)  

1 ug of RNA from day 2 plus 1 ug of RNA from day 14 cultures of Cor.At® cardiomyocytes

2 ug RNA total (1 ug per vial)

06133

 

 

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