|
|
Home > Pure
Cardiomyocytes
Cardiomyocyte Products
ReachBio is the Exclusive North American Distributor for
Axiogenesis AG, including the
Cor.AT® product line of pure cardiomyocytes and related products.
For a list of products, please
click here.
Cor.At®: Ready-To-Use Pure Cardiomyocytes
Cor.At® atrial cardiomyocytes are produced and genetically selected from mouse embryonic stem (ES) cells using cutting edge technology. They are 99.9% pure, ready to use and functionally normal. They exhibit autonomous contractility and embryonic electrophysiological and gene expression phenotypes. These transgenic cardiomyocytes
express green fluorescent
protein (GFP) reporter gene driven by a cardiac-specific promoter (α-MHC).
The cells generate
cardiac-specific connexin 43 and
show electrical coupling
demonstrated by their
synchronous contractions.
Major applications include:
|
|
 |
Flyer
|
-
In-vitro model of hypertrophy
- reproduce features of hypertrophic cardiomyocytes
when stimulated with specific agonists
-- increased cell size and sarcomeric organization
-- upregulation of hypertrophy-specific genes
|
 |
Flyer
|
-
Electrophysiology studies
- Represent an authentic cellular environment that
includes all cardiac ion channels (Na+, Ca2+, K+)
- hERG blocker effects
- chronotrophic effects
- arrhythmic effects
- Correct humoral regulation
- Adrenergic and muscarinic effects
|
 |
Flyer
|
|
|
|
|
-
Axiogenesis Cor.At® Products
|
Product
|
Description
|
Unit/Format
|
ReachBio Cat. #
|
|
Cor.At® Cells (vials)
|
Cor.At® cardiomyocytes (atrial)
99.9% pure
>750,000 viable cells/vial
Note: Bulk quantities available. Please contact us for info and prices.
|
Cryo Vial |
06101
|
|
Cor.At® Mod
|
Cor.At® cells custom-modified by request. Options include:
• pre-induced hypertrophy
• genetic modifications
• other
|
Cryo Vial
|
06102
|
|
Cor.At® Cells (plates)
|
96-well plate pre-seeded with Cor.At® atrial cardiomyocytes
(99.9% pure)
• 60 wells seeded
• >20,000 cells/well (590 cells/mm2)
|
96-well plate
|
06111
|
|
Cor.At® Tox
|
Complete Cardiotoxicity Test Kit
Kit Includes:
• 96 well plate (60 wells pre-seeded
with Cor.At® atrial cardiomyocytes
at >20,000 cells/well)
• 250 mL Cor.At® Culture Medium
• positive and negative controls vials
• NRU detection reagents |
Kit
|
06115
|
|
Cor.At® Cardio-Tox Validation Kit
|
Complete kit to validate your use of the Cor.At® Tox system.
Kit Includes:
• 3 x pre-seeded 96 well plate*‡
• 3 x 250 mL Cor.At® Culture
Medium*
• 3 x positive and negative control
vials*
• 3 x NRU detection reagent vials*
* all replicate items are from the same
manufacturing lot.
‡ 20,000 cells per well. 60 wells per plate
seeded. |
Kit
|
06117
|
|
Cor.At® Patch
|
Coverslips pre-seeded with Cor.At® atrial cardiomyocytes (99.9% pure)
• 1000 cells/coverslip
• Ready-to-use for electrophysiology
patch clamp applications |
Package of 10
|
06121
|
|
Cor.At® Culture Medium
|
Culture Medium for Cor.At® cardiomyocytes
• Optimized formulation
• Contains pre-qualified supplements
|
250 mL bottle
|
06099
|
|
Cor.At® RNA
|
Purified RNA from Cor.At® cells
|
100 ng
|
06131
|
|
Cor.At® RNA
|
Purified RNA from Cor.At® cells
|
1ug
|
06132
|
|