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Home > Pure
Cardiomyocytes
Cardiomyocyte Products
ReachBio is the Exclusive North American Distributor for
Axiogenesis AG, including the
Cor.AT® product line of pure cardiomyocytes and related products.
For a list of products, please
click here.
Cor.At®: Ready-To-Use Pure Cardiomyocytes
Cor.At® atrial cardiomyocytes are produced and genetically selected from mouse embryonic stem (ES) cells using cutting edge technology. They are 99.9% pure, ready to use and functionally normal. They exhibit autonomous contractility and embryonic electrophysiological and gene expression phenotypes. These transgenic cardiomyocytes
express green fluorescent
protein (GFP) reporter gene driven by a cardiac-specific promoter (α-MHC).
The cells generate
cardiac-specific connexin 43 and
show electrical coupling
demonstrated by their
synchronous contractions.
Major applications include:
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Flyer
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In-vitro model of hypertrophy
- reproduce features of hypertrophic cardiomyocytes
when stimulated with specific agonists
-- increased cell size and sarcomeric organization
-- upregulation of hypertrophy-specific genes
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Flyer
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Electrophysiology studies
- Represent an authentic cellular environment that
includes all cardiac ion channels (Na+, Ca2+, K+)
- hERG blocker effects
- chronotrophic effects
- arrhythmic effects
- Correct humoral regulation
- Adrenergic and muscarinic effects
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Flyer
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Axiogenesis Cor.At® Products
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Product
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Description
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Unit/Format
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ReachBio Cat. #
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Cor.At® Cells (vials)
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Cor.At® cardiomyocytes (atrial)
99.9% pure
>750,000 viable cells/vial
Note: Bulk quantities available. Please contact us for info and prices.
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Cryo Vial |
06101
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Cor.At® Mod
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Cor.At® cells custom-modified by request. Options include:
• pre-induced hypertrophy
• genetic modifications
• other
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Cryo Vial
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06102
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Cor.At® Cells (plates)
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96-well plate pre-seeded with Cor.At® atrial cardiomyocytes
(99.9% pure)
• 60 wells seeded
• >20,000 cells/well (590 cells/mm2)
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96-well plate
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06111
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Cor.At® Tox
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Complete Cardiotoxicity Test Kit
Kit Includes:
• 96 well plate (60 wells pre-seeded
with Cor.At® atrial cardiomyocytes
at >20,000 cells/well)
• 250 mL Cor.At® Culture Medium
• positive and negative controls vials
• NRU detection reagents |
Kit
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06115
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Cor.At® Cardio-Tox Validation Kit
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Complete kit to validate your use of the Cor.At® Tox system.
Kit Includes:
• 3 x pre-seeded 96 well plate*‡
• 3 x 250 mL Cor.At® Culture
Medium*
• 3 x positive and negative control
vials*
• 3 x NRU detection reagent vials*
* all replicate items are from the same
manufacturing lot.
‡ 20,000 cells per well. 60 wells per plate
seeded. |
Kit
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06117
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Cor.At® Patch
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Coverslips pre-seeded with Cor.At® atrial cardiomyocytes (99.9% pure)
• 1000 cells/coverslip
• Ready-to-use for electrophysiology
patch clamp applications |
Package of 10
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06121
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Cor.At® Culture Medium
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Culture Medium for Cor.At® cardiomyocytes
• Optimized formulation
• Contains pre-qualified supplements
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250 mL bottle
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06099
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Cor.At® RNA
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Purified RNA from Cor.At® cells
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100 ng
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06131
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Cor.At® RNA
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Purified RNA from Cor.At® cells
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1ug
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06132
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